Genomics, Epigenetics, Integrative omics, Genetic association studies, Statistical analysis
Louella has a Phd in Physics from the University of Warwick in the UK. She then joined the Wellcome Trust Sanger Institute as a Postdoc in the human genetics department and eventually held a Staff Scientist position. She has also worked in a Cambridge liquid biopsy diagnostics company as a Senior Data Scientist.
Over the years, she has been analysing multiomics data (transcriptomics, ChIPseq, DNA methylation, WGS) and integrating genetics to genomics in human complex traits and diseases. Her passion is to understand molecular pathways that could explain disease mechanism with the aim to identify biomarkers for potential therapeutic targets. She is also interested in gene regulatory pathways that are crucial for stem cell development towards lineage specification.
Louella joined the NBIS Long Term Support in February 2020 and is largely involved in multiomics projects.
Kundu, K., Mann, A. L., Tardaguila, M., Watt, S., Ponstingl, H., Vasquez, L., Morrell, N. W., Stegle, O., Pastinen, T., Sawcer, S. J., Anderson, C. A., Walter, K., and Soranzo, N. (2020) Genetic associations at regulatory phenotypes improve fine-mapping of causal variants for twelve immune-mediated diseases.
Watt, S., Vasquez, L., Walter, K., Mann, A. L., Kundu, K., Chen, L., Yan, Y., Ecker, S., Burden, F., Farrow, S., Farr, B., Iotchkova, V., Elding, H., Mead, D., Tardaguila, M., Ponstingl, H., Richardson, D., Datta, A., Flicek, P., Clarke, L., Downes, K., Pastinen, T., Fraser, P., Frontini, M., Javierre, B.-M., Spivakov, M., and Soranzo, N. (2019) Variation in PU.1 binding and chromatin looping at neutrophil enhancers influences autoimmune disease susceptibility.
Cheung, W. A. et al.
(2017) Functional variation in allelic methylomes underscores a strong genetic contribution and reveals novel epigenetic alterations in the human epigenome. Genome Biology
Chen, L. et al.
(2016) Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells. Cell
Astle, W. J. et al.
(2016) The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. Cell
Moreau, T., Evans, A. L., Vasquez, L., Tijssen, M. R., Yan, Y., Trotter, M. W., Howard, D., Colzani, M., Arumugam, M., Wu, W. H., Dalby, A., Lampela, R., Bouet, G., Hobbs, C. M., Pask, D. C., Payne, H., Ponomaryov, T., Brill, A., Soranzo, N., Ouwehand, W. H., Pedersen, R. A., and Ghevaert, C. (2016) Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming. Nature Communications
Vasquez, L. J., Mann, A. L., Chen, L., and Soranzo, N. (2015) From GWAS to function: lessons from blood cells. ISBT Science Series
Chen, L. et al.
(2014) Transcriptional diversity during lineage commitment of human blood progenitors. Science
Shin, S.-Y. et al.
(2014) An atlas of genetic influences on human blood metabolites. Nature Genetics
Rodriguez, A., Vasquez, L. J., Slevin, K., and Römer, R. A. (2010) Critical Parameters from a Generalized Multifractal Analysis at the Anderson Transition. Physical Review Letters
Rodriguez, A., Vasquez, L. J., and Römer, R. A. (2009) Multifractal Analysis with the Probability Density Function at the Three-Dimensional Anderson Transition. Physical Review Letters